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Ajay Kumar Singh

Ajay Kumar Singh

DSL Clinics, India

Title: Lymecycline in Dermatology


Biography: Ajay Kumar Singh


Lymecycline is a semi synthetic tetracycline antibiotic with improved oral absorption,enhanced tissue penetration and slower elimination relative to tetracycline.Lymecycline has been in clinical use for several decades in the proposed indications and has a well –established benign profile.Lymecycline generally bacteriostatic against a wide variety of organisms both gram positive and gram negative.These drugs enter gram negative bacteria by passive diffusion through hydrophilic channels formed by the porin proteins of the outer cell membrane and by active transport via an energy-dependent system that pumps all tetracyclines across the cytoplasmic membrane.Entry of these drugs into gram positive bacteria requires metabolic energy,but is not as well understood.This system is also believed to exist in gram positive bacteria.



Plasma t1/2: 8 (7-14) hrs

Time to peak concentration (tmax): 3 hrs (after 300mg PO)

Peak concentration (Cmax): 2.1 mg/L (after 300mg PO)

Around 30% of active drug excreted unchanged in urine

Water soluble prodrug of tetracycline (Better oral absorption)


 Lymecycline is a tetracycline broad-spectrum antibiotic

 Antibacterial and anti-inflammatory effects

 It inhibits ribosomal protein synthesis by preventing the association of aminoacyltRNA with the bacterial ribosome (30S subunit)

Bacteriostatic (Reversible association with ribosome)

Spectrum of action: Gram-positive and negative bacteria, chlamydiae, mycoplasmas, rickettsiae, spirochaetes, protozoan parasites (P. falciparum, Entamoeba histolytica, Giardia lamblia, Leishmania major, Trichomonas vaginalis, Toxoplasma gondii)


Acne,Rosacea,Perioral dermatitis,Chlamydia trachomatis infection,Reactive arthritis, Hidradenitis Suppurativa, M.marinum infection, Progressive macular hypomelanosis, Frontal fibrosing alopecia, Pyoderma gangrenosum


Hypersensitivity to tetracyclines.

Pregnancy or lactation in women breast feeding infants.

Advanced renal/hepatic insufficiency.

Concurrent treatment with oral retinoids

It has seen that during the treatment duration the acne lesion especially nodule and cysts have responded very well from Lymecycline in comparisons to Doxycyline moreover patients who developed some resistance to other systemic drugs, responded wonderful by Lymecycline 408 mg. There is also not seen any Phototoxic reaction with Lymecycline which are usually seen with Doxycycline. Patients have fewer side effects by lymecycline. Lymecycline is also found to be effective in patients with mild inflammatory papules and Pustules.



For other infections, the usual dosage is Lymecycline 408mg (equiv. tetracycline base 300mg) twice a day. If higher doses are required, 1224- 1632mg (3-4 capsules) may be given over 24 hours.